Acts especially on gastro-intestinal tract. Chronic catarrhal conditions, leucorrhœa and gonorrhœa. Obstinate ulcers. Useful in mental troubles from overweening pride. Especially useful in females. Nux symptoms in females often met by Gratiola.
Natural
Clinical Applications
Compare: Dig; Euph; Tab; Cham; Ammon pic; Nux vom .
Key Symptoms & Indications
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Acts especially on gastro-intestinal tract. Chronic catarrhal conditions, leucorrha and gonorrha. Obstinate ulcers. Useful in mental troubles from overweening pride. Especially useful in females. Nux symptoms in females often met by Gratiola.
Physical Symptoms
Head
Sick headache. Rush of blood with vanishing of sight. Sensation as if brain was contracting and head became smaller. Tightness in forehead, with wrinkles in skin. Eyes dry, burn. Myopia.
Stomach
Vertigo during and after meals; hunger and feeling of emptiness after meals. Dyspepsia, with much distention of the stomach. Cramps and colic after supper and during night, with swelling of abdomen and constipation. Dysphagia for liquids.
Stool
Diarrha; green, frothy water , followed by anal burning, forcibly evacuated without pain. Constipation , with gouty acidity. Hæmorrhoids, with hypochondriasis. Rectum constricted.
Sleep
Insomnia.
Female
Nymphomania . Menses too profuse, premature, and too long. Leucorrha.
Modalities (Better / Worse)
Worse (Aggravation)
, drinking too much water
Better (Amelioration)
No specific amelioration factors listed.
Mentions in Classic Materia Medicas
Explore detailed descriptions for this remedy across famous historical textbooks:
GRATIOLA OFFICINALIS
Sick headache. Rush of blood with vanishing of sight. Sensation as if brain was contracting and head became smaller. Tightness in forehead, with wrinkles in skin. Eyes dry, burn. Myopia.
Vertigo during and after meals; hunger and feeling of emptiness after meals. Dyspepsia, with much distention of the stomach. Cramps and colic after supper and during night, with swelling of abdomen and constipation. Dysphagia for liquids.
Diarrhœa; green, frothy water, followed by anal burning, forcibly evacuated without pain. Constipation, with gouty acidity. Hæmorrhoids, with hypochondriasis. Rectum constricted.
Insomnia.
Nymphomania. Menses too profuse, premature, and too long. Leucorrhœa.
Worse, drinking too much water.
Compare: Dig; Euph; Tab; Cham; Ammon pic; Nux vom.
Second to third potency.
Gratiola.
Cholera. Coccygodynia. Constipation. Cramps. Diarrhœa. Dropsy. Eyes, affections of. Gastralgia. Gout. Hæmorrhoids. Headache. Hydrocephalus. Hypochondriasis. Hysteria. Mania. Masturbation. Mesenteric glands, affections of. Neuralgia. Nymphomania. Tetanus. Vision, disordered.
Gratiola is one of the most important members of the great Scrophularian group─Digit., Euphras., Tabac., Scroph.─and should be carefully studied with these. A large proportion of the effects of Gratiola are expended on the gastro-intestinal tract. It is an inodorous plant, of bitter taste, and very poisonous, causing violent colic, diarrhœa, bloody stools, enteritis, jaundice, trembling of extremities, convulsions, cramps, excitement and disordered condition of the sexual powers, and death. Symptoms of a fully developed, rapid attack of Asiatic cholera are produced. On the other hand, the mind is strongly affected. Peevishness, ill-humour; irresolute; hysterical; cerebral affections without fever. It is useful in mental troubles from overweening pride. Teste considers Gratiola the Chamom. of chronic diseases. There is < during and after eating: vertigo during and after a meal. Hunger after a meal with feeling of emptiness. The diarrhœa is yellowish, gushing, watery, as though rushing from a hydrant. There is also vomiting of yellowish fluid. Summer diarrhœa from excessive drinking of water whether cold or hot. Soreness, burning or irritation of anus follows the stools. Two excellent cures with Gratiola have been recorded by C. W. Sonnenschmidt (H. R., xi. 547). (1) Mrs. C., 53, attacked in June with diarrhœa; yellow, watery, frothy stools gushing out with force. Severe cutting pains in abdomen; rumbling of flatulence. Occasional nausea and vomiting. Coloc. and Ipec. failed to relieve; then on close inquiry it was elicited that "a cold feeling in the abdomen" had been a feature throughout. Grat. off. 3, cured promptly. (2) A three-weeks' old infant was attacked with diarrhœa and colic. There were two or three passages in quick succession, and then an interval of an hour or two. Passages green or yellow, watery, frothy, expelled suddenly; nausea, vomiting, severe pain before stools, relieved after, for a short time. Cham., Coloc., Verat. failed and Grat. rapidly cured. It also removed in this case "redness around anus, and on one side an abrasion of half an inch in extent, which caused some oozing of blood." E. E. Case (Med. Adv., xxix. 343) cured a woman, æt. 50, of hæmorrhoids with the following symptoms: (1) Constipation, difficult stools. (2) External piles from any exertion and after stool. (3) Biting, stinging tension in tumours. (4) During stool, a sensation as if the rectal membrane was torn. (5) After stool, all the nerves of the pelvis seem in a high state of tension; the flesh on the perineum feels as if torn from the bone. [Compare "Wrenching pain in coccyx."] Sleepless before midnight; peevish; melancholy. Grat. 200 cured. Cooper has used it with great success in a case of gouty acidity with great constipation; and in the constipation of cancer. He regards it as "the vegetable antacid." It is said to have formed the basis for a once famous nostrum for gout, "Eau Médicinale." Indications are: Constant sinking but cannot eat; bitter taste. The affection of the solar plexus is very marked; cramps beginning at pit of stomach, and pains radiating therefrom; anxiety; gnawing; empty feeling; rolling about in epigastric region. Urine is diminished, reddish, turbid. Buvier, says Teste, saw four cases of nymphomania in females to whom herb-doctors had given injections of a decoction of freshly gathered Gratiola. Burnett considers it specific in female masturbation and nymphomania. A number of pains are experienced in the coccyx. Chilly; shuddering on entering a warm room. Heat ascending to face, with redness and increased external warmth. Constant vaporous exhalation from body. Sensations: as if brain contracted; as if head grew smaller; as if brain would fall forward; as if sand in eyes; as if throat contracted; as if a stone rolling from side to side in stomach. The left side is more affected than the right. The head and eye symptoms are of the first importance. Rush of blood to head with vanishing of sight I consider a keynote. With Grat. 30. I cured this symptom in a patient: "Sometimes everything seems to assume a yellowish tint, and occasionally, when I have been taking notes, a rush of blood to my head seems to shut the book from my sight and for the moment I have been unable to follow the speaker by writing although I could by thought." Motion <; rest >. > In open air; < in warm room (some headaches, and vertigo have the opposite modality). Coffee = neuralgia.
Antidoted by: Caust., Bell., Euphorb., Nux v. It antidotes: Iodum. Compare: Apis, Bell., Helleb., Cham., Nux v., Elat., Pod. Hunger after meals with feeling of emptiness, Lauro., Calc., Cascaril., Chi., Cin.; (emptiness after stool, Petrol.); vanishing of sight and headache, Gels.; botanical, Dig., Euphr., Scroph.
Abuse of coffee.
Serious, taciturn, absorbed in reverie.─Self-concentration.─Irresolute, want of perseverance.─Ill-humour, tired of life, apprehensive of the future; hysteria; hypochondriasis.─Loquacity and gaiety.
Whirling vertigo on shutting the eyes.─Vertigo when reading, and when seated, as if the head were waving backwards and forwards.─Headache, with nausea and drowsiness.─Intoxicated feeling during and after a meal.─Rush of blood to the head and feeling as if intoxicated in whole brain.─Violent rush of blood to head, with throbbing in forehead amounting to vertigo, with blackness before the eyes; < by motion, esp. riding, increasing even to loss of consciousness, only disappearing after several hours' sleep.─Pressive headache, esp. in the forehead and occiput.─Lancinating and pulsative headache.─Sensation of heaviness in the forehead, as if the brain would fall forward, with stoppage of the nose.─Sensation as if the head were shrinking from contraction of the brain.─Sudden attack; sudden vibration in the head, which suspends the senses of sight and hearing.─The headache is < when rising from a seat, during movement, and while walking in the open air.─The head is very sensitive to cold.─Heat in the head, on raising the head.─Tightness in the forehead with wrinkles in the skin.
Itching, quivering, and sensation of weakness in eyelids.─Itching of eyelashes.─The eyes feel dry and as if sand were in them.─Burning pain and pressure on the eyes.─Eyes watery and weak when reading.─Mist before eyes, when reading or writing.─Myopia on reading.─Sees distant objects better than near ones.─While writing, or looking at light objects, sight suddenly vanishes; > by closing eyes, but constantly returns.─All objects seem white on opening the eyes, even green trees and turf.
Tearing and shootings in ears.─Itching of the ears.
Frequent sneezings, with shootings in l. side of the chest and of the hypochondria.─Stoppage of the nose.─Smarting-itching in l. nostril.─Pressure at upper part of nose.
Burning heat and redness of the face.─Tingling-burning in malar bones.─Sensation of tension in the face; it feels swollen.─Swelling of upper lip (every morning, with stinging).─Tearing on one side of face.─Painful crack in l. side of chin.
Nocturnal tearing or piercing in the molars.─Sensation of cold in the teeth.
Accumulation of much saliva in the mouth.─Accumulation of clear water in the mouth.─Mouth bitter or clammy.─Tongue rough, covered with mucus.─Fetid breath in the morning after waking.
Pressure in throat, as from thick mucus.─Accumulation of mucus in throat.─Pain in throat obliging one to swallow constantly; the swallowing is difficult, as if the throat were contracted; < during empty deglutition.─Stinging in throat (l. side).─Tingling, roughness, and scraping in throat.─Phlegm in throat, with inability to throw it off.
Gnawing, as from hunger after eating.─Constant sinking at epigastrium, but cannot eat.─Hunger, sometimes with loathing and horror of all food.─Increased thirst.
Bitter or sweetish risings.─Ineffectual efforts to eructate, with pressure from stomach to throat, which suspends respiration.─Empty or cold feeling in stomach.─Hiccough.─Regurgitation of bitter water.─Constant nausea, with retching.─Nausea, with cold in the abdomen.─Vomiting, with stoppage of the nose.─Bilious vomiting, or vomiting of acid or bitter substances.─Uneasiness, and sensation of fulness in stomach.─Pressure on the stomach after a meal, with nausea.─Searching and digging in the stomach, with inclination to vomit.─Pressure on the epigastrium after a meal, as from a stone; which moves back and forth.─The sufferings of the stomach and of the epigastrium are often accompanied by nausea, or ineffectual efforts at eructation.─Paroxysms of inclination to vomit, > by eructations.─Rolling about in epigastrium.
Shooting pains in the abdomen.─Beatings in l. hypochondrium (heating pain, burning).─Pressive pain in abdomen, with pinchings (in umbilical region), which force the patient to bend double (> by the emission of flatulence).─Inflation of the abdomen.─Flatulent and pressive colic, with nausea and disagreeable risings.─Rumbling, with nausea, eructation, and vertigo.─Feeling of coldness in abdomen, lasting half all hour.
Urgent and fruitless want to evacuate.─Constipation.─Fæces, hard, scanty, and tenacious, expelled with great effort.─Nocturnal slimy diarrhœa, with tenesmus.─Diarrhœa: stools, watery yellow-green, succeeded by burning at the anus; green frothy, coming out with great force.─Stools with burning and protrusion of large stinging-burning tumours.─Passage of fæces without being conscious of it.─Discharge of ascarides.─Pain, as from excoriation in the rectum.─Burning pain in the rectum, during and after the evacuation.─Shootings, itching, smarting, and throbbing in the anus.─Blind hæmorrhoids.
Diminished secretion of urine.─Scanty and reddish urine, which becomes turbid on standing, with cloudy sediment.─Burning in the urethra during and after micturition.
Stitches in l. spermatic cord, ascending through the abdomen up to the chest.─Painful rigidity of the penis after pollutions.─Drawing pain in glans.
Catamenia premature, too profuse, and of too long duration.─Masturbation.─Nymphomania.─Irritable condition of sexual organs, with congestions.─Shootings in r. breast, < on rising, during menses.
Dry cough, excited by a sensation of roughness in the chest, esp. in the morning or at night.─Nocturnal cough, with pain as from excoriation in the trachea, oppression of the chest and shivering.─Choking when ascending.
Heat in the chest, then the head and hands, with redness of the face.─Pressure on the chest.─Shootings in the chest on breathing.─Pimples on the chest, which burn after having been scratched.
Palpitation of the heart.─Violent palpitation, particularly immediately after a stool, and with oppression of the chest.
Sensation as if the neck were seized with the hands.─Darting from the l. scapula to the shoulder and mamma.─Sticking pain in lower dorsal vertebræ; in r. kidney.─Bruised pain in loins.─Painful cramps in coccyx.─Pressive or wrenching pain in coccyx after stool.
Rheumatic pains in the shoulders, arms, fingers, particularly in elbow and wrist-joint.─Itching in the palm of the (r.) hand.
Bruised pain in the thigh, after a short walk.─Lancinating tearing in tibia when sitting, disappearing when walking.─Smarting itching on tibia.─Shootings in legs and feet.
Tearing in the limbs.─Tetanus, with full consciousness while lying down after a meal, followed by a deep sleep with emission of semen; bruised feeling of the body, back and l. arm on waking.─The majority of symptoms appear at night, or when sitting, and after rising from a seat, or in the open air; contact > them.─Great languor and prostration.─Great loquacity and gaiety.
Itching with burning after scratching.─Running and corrosive eruptions, which resemble scabies.
Irresistible drowsiness with yawning.─Great drowsiness, with frequent yawning and inclination to lie down, esp. in the afternoon.─Deep sleep, like stupor.
Pulse small, intermittent.─Great tendency to chilliness.─Chilliness in a warm room, during sleep, after an evacuation; with the hair standing on end.─Heat ascending to the face, with redness and increased external warmth.─Constant vaporous exhalation from the body.
Gratiola officinalis
Gratiola officinalis
• Though this remedy acts especially on the gastro-intestinal tract; it has some mental and sexual symptoms also.
• Paralytic pains and feeling of coldness esp. in the abdomen are marked symptoms.
• Neuralgia due to abuse of coffee.
• Mental effects from overweening pride.
• Nervous prostration.
• Eating.
• Drinking too much water hot or cold.
• Summer.
• Motion.
• Abuse of coffee.
• Dinner.
• Open air.
• Weak will.
• Ill humour; tired of life, want of perseverance.
• Apprehensive of future.
• Hysteria.
• Nymphomania.
• Hypochondriasis.
• Rush of blood, with vanishing of sight.
• Vertigo, during of after meals. Forehead wrinkled during headache.
• Sensation as if brain were contracted and head became smaller.
• All objects seem white, even green trees.
• Emptiness after eating.
• As of a cold water or loose heavy load in stomach.
• Craves nothing but bread.
• Profuse, yellowish, green, gushing, watery or frothy exhausting diarrhoea, with, coldness in the abdomen, followed by soreness or burning of anus.
• Summer diarrhoea, from drinking of excess of water.
• Painful rigidity of the penis, after seminal emission; nightly.
• Tendency to masturbation; nymphomania.
• Menses; too profuse; premature and too long.
• Leucorrhoea, persistent.
• Darting pain in mammae (R) when stooping, during menses.
• Palpitation; after stools, with oppression of chest.
• Pain in coccyx, after stool.
• Neck as if seized by hands.
• Limb gives way with sciatic pain.
• Mag-c.
Gratiola
Diarrhoea of yellow, or greenish yellow watery stools, forcibly evacuated, and followed by burning in the anus.
Gratiola
It is a great remedy for nervous prostration; marked lassitude, with mental and bodily weakness. It is closely related to Coffeaand Nuxvomicaand especially useful for the weakness of the will and neuralgic pains in coffee drinkers. In hypochondria and in the female it has melancholia and nymphomania. Convulsive conditions without loss of consciousness.
Complaints are better in the open air, but he is chilly in a warm room (like Pulsatilla); complaints predominate on the left side; constant vaporous exhalations from the body. Catarrhal conditions of the stomach and intestines with spasmodic ailments.
There is a lack of will power and aversion to work; mental depression and capriciousness; he is very irritable and hypochondriacal; fear of the future. Complaints from pride. Bad effects from coffee and alcohol; nervous complaints associated with stomach and bowel troubles.
Vertigo during and after eating; on closing the eyes; while reading; on rising from a seat; on motion; vertigo with cerebral hyperemia. Heat and fullness of the head; sensation as though the head grew smaller; pulsation in head; in temples; rush of blood to head, after rising from stooping.
The head symptoms are better in the open air and worse or come on in warm room. Pain in the occiput in the morning on waking, better rising or lying on the face. Sick headaches, nausea, vomiting or disgust for food, with vertigo, better in the open air.
Pain in occiput from sneezing. The head feels cold and is sensitive, to cold air. Cold sensation of vertex. Corrugated forehead during the headache. Itching of the scalp; itching of the eyes and ears. Mist before the eyes while reading and green objects appear white.
Pain in eyes as from sand; itching in the nose. There is a sensation of burning heat in the face, but it feels cold to the hand.
Swelling of the upper lip in the morning. There is a sensation of tension of the face and tingling and it feels swollen. The face is red; the teeth ache from cold things taken in the mouth. Grinding of teeth in brain affections.
Pain in the throat, compelling constant swallowing; much mucus in the throat, which he cannot eject. Violent thirst; emptiness in the stomach after eating; emptiness when he does not need or desire food. Craves nothing but bread.
Nausea better after eating and by eructations. Vomiting of bitter, sour water and mucus. A feeling of anxiety in the stomach. Cramping in the stomach after food and a heavy load that seems to go from side to side as he turns from side to side, with nausea and eructation. Distension after eating. Pressure in stomach, after eating. Marked coldness in stomach. Cramp and hard aching in stomach, pain grows rapidly worse and seems to extend to back and kidneys.
Cold feeling in abdomen. Cramping like colic with nausea. Rumbling in abdomen with distension in afternoon and evening. Swelling of mesenteric glands. Pinching in abdomen, better by passing flatus. Diarrhoea, with copious gushing, yellow or yellowish-green, frothy, watery stools; copious watery vomiting and purging, like. cholera morbus; copious green watery stools. The diarrhoea is brought on. from drinking large quantities of water, due to the violent thirst.
During the diarrhoea he is often sensitive to draft and open air which give him urging to stool. It has cured fully developed, rapid, Asiatic cholera. Green stools and green vomiting, unconscious stools.
Before stool, nausea; rumbling, cutting; tenesmus. During stool, nausea; burning in rectum straining. After stool, burning in rectum; tenesmus; pain in coccyx creeping chills; pain in abdomen.
Protrusion of stinging, burning hemorrhoids. Tearing and pricking in anus. Constriction in anus; itching anus. Ascarides. Burning in the urethra during and after urination; scanty urine becomes turbid on standing; unconscious discharge of urine. Stitching in left spermatic cord to abdomen and chest.
It is a most useful remedy in the female when there is marked irritability of the sexual organs, if the sexual desire is great excited; it is one of our best remedies for nymphomania. When the desire is so violent that it drives her to secret vice the remedies are Gelsemium, Gratiola, Origanum, Nux vomica, Phosphorus, Platina and Zincum.
The menses are too early and profuse; darting pain in right mamma when stooping and during menses worse on rising; leucorrhea with pains in sacrum.
Violent palpitation after stool (Conium) with oppression of chest heat in chest, head, hands, with red face.
Rheumatic pains in upper limbs; sore bruised pains in lower limbs, after walking, tearing in the tibia while sitting, better while walking.
Sleepiness after eating; deep sleep, Itching and burning of the skin, after scratching.
Gratiola Officinalis.
Mind and Disposition.
Serious, taciturn, absorbed in reverie.
Irresolute, want of perseverance.
Ill-humor, tired of life, apprehensive of the future.
Head.
Vertigo, while reading ; on rising from a seat.
[5] Intoxicated feeling during and after a meal.
Pressure in the forehead, with vertigo.
Sensation of heaviness in the forehead, as if the brain would fall forward, with stoppage of the nose.
Heat in the head, on raising the head.
Tightness in the forehead with wrinkles in the skin.
[10] The headache is aggravated by rising from the seat and by walking in the open air.
The head is very sensitive to cold.
Itching of the scalp.
Eyes.
Itching of the eyelashes.
The eyes feel dry and as if sand were in them.
[15] Mist before the eyes, when reading or writing.
Short-sightedness, with burning heat in the face.
Ears.
Itching of the ears.
Nose.
Smarting-itching in the left nostril.
Pressure at the upper part of the nose.
Face.
[20] Burning heat in the face.
Tingling-burning in the malar bones.
Sensation of tension in the face ; it feels swollen.
Swelling of the upper lip (every morning) (with stinging).
Mouth and Throat.
Accumulation of clear water in the mouth.
[25] Tongue rough, coated with mucus.
Fetid breath on waking.
Pain in the throat obliging one to swallow constantly ; the swallowing is difficult, as if the throat were contracted ; worse during empty deglutition.
Stinging in the throat (left side).
Phlegm in the throat, with inability to throw it off.
Stomach and Abdomen.
[30] Hunger without appetite.
Violent thirst.
Hiccough.
Gulping up of bitter substances.
Paroxysms of inclination to vomit, relieved by eructations.
[35] Empty retching.
Pressure in the stomach after every meal.
Empty or cold feeling in the stomach.
Gnawing, as from hunger after eating.
In the left hypochondrium heating pain, burning.
[40] Pinching in the umbilical region, relieved by emission of flatulence.
Cold feeling in the abdomen.
Rumbling, with nausea, eructations, and vertigo.
Stool and Anus.
Diarrhoea ; stools, watery yellow-green, succeeded by burning at the anus ; green frothy, coming out with great force.
Stools with burning and protrusion of large, stinging-burning tumors.
[45] Passage of feces without being conscious of it.
Discharge of ascarides.
In the rectum soreness ; burning during and after stool.
In the anus stinging, itching.
Urinary Organs.
Scanty reddish urine, becoming turbid while standing.
[50] Floculent sediment in the urine.
Burning in the urethra during and after micturition.
Genital Organs.
Men. Stitches in the left spermatic cord, ascending through the abdomen up to the chest.
Involuntary emission succeeded by a painful erection.
Women. Menses too early and too profuse.
[55] Nymphomania.
Dartings in the right mamma.
Respiratory Organs.
Heat in the chest, then in the head and hands, with redness of the face.
Violent palpitation of the heart, particularly immediately after stool, and with oppression of the chest.
Back and Neck.
Sensation as if the neck were seized with the hand.
[60] Darting from the left scapula to the shoulder and mamma.
Extremities.
Upper. Rheumatic pains in the shoulders, arms, fingers, particularly in the elbow and wrist joint.
Itching in the palms of the (right) hand.
Lower. Bruised pain in the thigh, after a short walk.
Lancinating tearing in the tibia when sitting, disappearing when walking.
[65] Smarting-itching on the tibia.
Sleep.
Irresistible drowsiness with yawning.
Deep sleep, like stupor.
Fever.
Pulse small, intermittent.
Chilliness in a warm room, during sleep, after an evacuation ; with the hair standing on end.
[70] Heat, ascending to the face, with redness and increased external warmth.
Constant vaporous exhalation from the body.
Generalities.
Physical and mental depression.
Great languor and prostration.
Tetanic condition, without loss of consciousness, while lying down after a meal, followed by a deep sleep with emission of semen ; bruised feeling of the body, back and left arm on waking.
Skin.
[75] Itching, with burning after scratching.
Conditions.
Aggravation on sitting, or on rising from a seat ; in the after noon ; after a meal.
Amelioration by contact.
GRATIOLA OFFICINALIS
REGION:
Gastro-intestinal tract.
Mind.
Sexual organs.
WORSE:
Eating.
Drinking too much water.
Summer.
Motion.
Coffee.
Dinner.
Atony. Paralytic pains. Coldness. .................... Weak will. Hypochondriasis. Emptiness after eating. As of cold water or a loose, heavy load in stomach. Profuse, gushing, watery or frothy, yellow-green, exhausting stools, then relief (Gamb.). Nightly emissions, then erections. Nymphomania. Coccygeal pain. Limb gives way, with sciatic pain.
REMEDY RELATION
Related: Mag-c.
Clinical Tips & Practitioner Insights
"CINA is a great remedy for xanthopsia. There is a yellow tint imparted to landscapes and objects looked at.These are effects perhaps most comparable to that of looking through yellow glass."
"The most careful analysis of clinical experience has demonstrated that CINA is most powerful for the elimination of round worms."
Remedy Profile
- Type Remedy
- Common Name HOMOPATHIC MATERIA MEDICA by William BOERICKE, M.D. Presented by Médi-T
- Origin Source Natural
Dosage & Potency
Second to third potency.
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